Miner-turned-dentist McTeague wins young Trina Sieppe away from her cousin Marcus, McTeague`s friend. When Trina wins five thousand dollars in a lottery, Marcus accuses McTeague of marrying her for her money. Trina becomes more and more obsessed with money, refusing to spend any of her winnings even though she and her husband are forced into dire straits. When Marcus informs the authorities that McTeague is not licensed as a dentist, thus depriving him of his meager living, the friendship and the marriage are destroyed. At last murder intrudes, leaving no one unscathed.