Brian is a conservative-leaning newspaper columnist who voted for George W. Bush over Al Gore, enjoys the single life over married life, and isn`t afraid to voice his opinions, even when it means not having sex with politically liberal hot women. His friends include house-husband Craig Tindle, who is "whipped" by his neoconservative Korean wife, Hu, and teacher Jimmy Townhouse, a moderate Democrat who tries to bring his Republican friend off his high horse. Brian and his friends spend their time drinking at a local bar and commenting on the week`s events as they unfold via TV news as they`re served drinks by attractive Latina bartender Sami Ruiz, who Brian wouldn`t mind sleeping with if she didn`t support Ralph Nader. The series finds the group encountering caricatures of known figures like Wayne Brady, who is running for president, a drunken Ted Kennedy, and George W. Bush.
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