威尔·史密斯
Willard Christopher Smith Jr
饰：本内特·奥马鲁博士 Dr. Bennet Omalu
亚历克·鲍德温
Alec Baldwin
饰：朱利安·贝勒斯 Dr. Julian Bailes
古古·姆巴塔-劳
Gugu Mbatha-Raw
饰：帕拉马·姆提索 Prema Mutiso
艾利斯·霍华德
Arliss Howard
饰：约瑟夫博士 Dr. Joseph Maroon
保罗·雷瑟
PaulRiser
饰：埃利奥特博士 Dr. Elliot Pellman
卢克·威尔逊
Luke Wilson
饰：罗杰·古德尔 Roger Goodell
阿德沃尔·阿吉纽依-艾格拜吉
Adewale Akinnuoye-Agbaje
饰：戴夫·杜尔森 Dave Duerson
大卫·摩斯
David Morse
饰：麦克·韦伯斯特 Mike Webster
阿尔伯特·布鲁克斯
Albert Brooks
饰：西里尔·韦契特 Dr. Cyril Wecht
Phillip Chorba
饰：Tech,(as Phillip JM Chorba)
乔舒亚·里斯
Joshua Reese
饰：Graveyard Tech
埃迪·马森
Eddie Marsan
饰：Dr. Steven DeKosky
史蒂芬·莫耶
Stephen Moyer
饰：Dr. Ron Hamilton
马修·维利希
Matthew Willig
饰：Justin Strzelczyk
比茜·图诺克
Bitsie Tulloch
饰：Keana Strzelczyk
威廉·卡尼亚
William Kania
加里·格鲁布斯
Gary Grubbs
饰：FBI Agent
莎拉琳赛
Sara Lindsey
饰：Gracie
Nathan Hollabaugh
饰：Young Reporter
Dennis Matthews
杰森·戴维斯
Jason Davis
饰：Defense Attorney
Jared Pfennigwerth
饰：Tech
Kevin Jiggetts
Kevin Jiggetts
饰：FBI Agent
理查德·琼斯
Richard T.Jones
饰：Andre Waters
布丽坦妮·约翰逊
Britanni Johnson
饰：Rachel Green
迈克·奥麦利
Mike O'Malley
饰：Daniel Sullivan
丹·茨斯基
Dan Ziskie
饰：Paul Tagliabue
Alison Moir
饰：Colleen Bailes
兰迪·科维茨
Randy Kovitz
饰：Deputy Mayor
克里斯托弗·波耶尔
Christopher Boyer
罗佰特·麦凯
Robert McKay
Peter Muggleworth
Peter Muggleworth
Joni Bovill
Joni Bovill
饰：Mrs. Scott
帕特里克·卡恩斯
Patrick Kearns
萨玛拉·李
Samara Lee
饰：Strzelczyk's Daughter
Rocky Paterra
Rocky Paterra
Rajeev Pahuja
Rajeev Pahuja
Wendell Kinney
Wendell Kinney
艾姆·伊克瓦科
Eme Ikwuakor
Jeb Keller
Jeb Keller
Da'shawn Thomas
Da'shawn Thomas
Kirsten McCain
Kirsten McCain
Ben McDonnell
Ben McDonnell
Joe Fishel
Joe Fishel
Jim Fitzgerald
Dan Anders
饰：College Coach,(as Dan D.A. Anders)
Troy Bogdan
Nicholas Augusta
Nicholas Augusta
Mark Falvo
Mark Falvo
Carmen Gangale
Carmen Gangale
Joe Gallipoli
Joe Gallipoli
Lloyd Crago
Lloyd Crago
Jennifer Boch-Wawrzyniak
Jennifer Boch-Wawrzyniak
Doug Roberts
Doug Roberts
Jennifer Nicole Baker
Jennifer Nicole Baker
Cara Clark
Cara Clark
Paul Wallis
Paul Wallis
Jennifer Pearl Childers
Jennifer Pearl Childers
Deborah Charity
Deborah Charity
Norman Cardaro
Norman Cardaro
Robin Flak
Robin Flak
Tyler Cheman
Tyler Cheman
Ralph Browning
Ralph Browning
Nateice Aisha
Nateice Aisha
Richie Acevedo
Richie Acevedo
Van J. Terry
Van J. Terry
Ed Mihalacki
Ed Mihalacki
Richard Guesman
Robert Graziosi
David Gragg
James Howard
James Howard
Kristy Isenberg
Kristy Isenberg
Trevor Lee Georgeson
Trevor Lee Georgeson
John W. Iwanonkiw
John W. Iwanonkiw
辛迪·杰克逊
Cindy Jackson
饰：Paramedic
Scott Lockhart
蒂凡妮·桑德尔·麦肯兹
Tiffany Sander McKenzie
菲尔·纳多兹
Phil Nardozzi
James Lloyd
David Dale McCue
Jackson Nunn
Jackson Nunn
Edward Pfeifer
Brent Reichert
Dwayne Pintoff
Laura Lukasik
Chris Jameson
Chris Jameson
F. Robert McMurray
F. Robert McMurray
特丽·米德尔顿
Terri Middleton
Jeff Seich
Jeff Seich
Jeffrey Neil
Jeffrey Neil
Mike Kuse
Mike Kuse
Will Steckman
Will Steckman
Eric Rasmussen
Eric Rasmussen
Don Nowacki
Don Nowacki
Leonard Lies Jr.
Leonard Lies Jr.
Kevin Slone
Kevin Slone
Mike Karban
Mike Karban
Electa Rawls
Electa Rawls
弗兰基·帕隆比
Frankie Palombi
Brittney A. Thomas
Brittney A. Thomas
David Shurin
David Shurin
Jeff Smith
Jeff Smith
Michael Allen Mlynar
Michael Allen Mlynar
Mike Walker
詹姆斯·威乐
James Werley
Laura Welsh
Dallas White
Dallas White
Frank Wilson
Frank Wilson
Megan Leigh Valentino
Megan Leigh Valentino
Kym Whitehead
Kym Whitehead
Holly Westerman
Holly Westerman
Logan J. Woolfolk
Logan J. Woolfolk
Raymond Wade Jr.
Raymond Wade Jr.
Kelly Trumbull
Kelly Trumbull
希尔·哈勃
Hill Harper
饰：Christopher Jones
Stephanie Haff
Jared Scott
Jared Scott
盖里·格拉伯斯
Gary Grubbs
饰：FBI Agent #2
斯科特·卡德维尔
L. Scott Caldwell
饰：Waters' Mother
Larry John Meyers
Larry John Meyers
饰：Father D'Amico
霍特·麦克卡兰尼
Holt McCallany
饰：Angry Neurologist
Mike Clark
饰：TV Reporter (Interview)
Joshua Elijah Reese
饰：Graveyard Tech
凯莉·戴维斯
Kelley Davis
饰：Assistant
Dino Rende
Dino Rende
饰：Strzelczyk's Son
Dihlon McManne
饰：Reporter at Westin