The Killer in My Family tells the story from the perspective of a murderer's family, exploring the impact their relative's crime had on them. Episodes feature interviews with family members and ex-partners of notorious murderers such as Ian Huntley, Fred West, Richard Ramirez, Phillip Fraser, Levi Bellfield and those involved in the honour killing of Surjit Athwal. Each story includes news coverage, personal archive, testimonies from police officers and journalists involved in the case, and psychological analysis from experts exploring how the family dealt with the trauma.